It depends on where the problem is.

If the wrinkles are on your face — eye contour, forehead, expression lines — the starting point is the Silk Peptide Serum. The Golden Silk Matrix™ works in the very first 0.02 mm, where expression lines form — exactly where no classic cream can reach.

If the main problem is the neck — sagging skin, horizontal lines, loss of firmness — the choice is the Neck Cream with Matribust®.

Many customers use them together: the serum for the face, the neck cream as a dedicated treatment.

The skin has a natural shield — the stratum corneum — that blocks almost everything you apply on the surface. Retinol, hyaluronic acid, classic peptides: they get that far and stop.

The silk peptides in the Golden Silk Matrix™ have a molecular structure small enough to cross it. Once inside, they weave into a protein micro-net that supports the skin exactly where it has folded. Acetyl Hexapeptide-8 gradually reduces the intensity of the muscle contractions that deepen expression lines. The result is structure — not surface hydration.

Because its internal structure is different.

Under the skin of the neck there is an invisible support network — the dermal-epidermal junction — that keeps the two layers of the skin anchored together.

Over time this network detaches, and the skin loses the internal support that kept it taut.

That's why face creams, even the best ones, don't work on the neck: they are not formulated to act on that specific structure.

The Serum is built around the Golden Silk Matrix™ — silk peptides that cross the skin barrier and support the face where expression lines form.

The Neck Cream contains Matribust® (patented by SILAB, 2.5%) — the active that works directly on the dermal-epidermal junction to re-anchor the two layers of the skin that have separated, plus Acetyl Hexapeptide-8 to reduce the contraction of the platysma muscle, the one behind the vertical bands on the neck.

Two different areas, two different mechanisms.

Yes — and it's the combination we recommend.

The two products work on different areas with complementary mechanisms, without overlapping. The Serum treats the face (and goes down to the chin); the Neck Cream starts from the jaw downward, with a formula specific to the structure of the neck.

They don't get in each other's way: they complete each other.

The ideal routine is to apply the Serum on the face first, then the Neck Cream on its dedicated area.

You can try risk-free.

If you're not satisfied with the results, you can use our 99-day satisfied-or-refunded guarantee, which provides a full refund.

Fewer than 1% of customers have asked for it — which shows how well the products work.

It depends on the product and the area treated.

With the Serum, many customers notice a perceptible tightening effect within the first weeks. The most visible changes emerge between the fourth and sixth week of consistent use.

With the Neck Cream, results on the structure of the neck take slightly longer — the area is more complex and the dermal-epidermal junction reorganises progressively. The first differences appear around the sixth week; the most significant transformation between 60 and 90 days.

That's why the guarantee on every Peptolia product lasts 99 days: you get the time you need to see the full difference before deciding.

Yes — and they were developed specifically for this profile. Mature skin has already been through years of aggressive routines, often with irritating ingredients such as high-concentration retinol or chemical peels.

Peptolia formulas contain no perfume, artificial colourants or agents known to irritate sensitive skin.

All products are dermatologically tested.

If you have a specific skin condition or are under dermatological treatment, we recommend consulting your doctor before use.

Peptolia products are developed in compliance with European cosmetic regulations, among the strictest in the world, and are cruelty-free and vegan.

The formulas are made following high quality standards and safety controls, and are designed for daily use even on sensitive skin.

Out of transparency, we don't advertise superfluous or misleading certifications: we prefer to focus on selected ingredients, tolerance and visible results.

The full ingredient list (INCI) is always available in the dedicated section of every product page.